Autism symptoms reversed in lab

This is cool. Some symptoms of autism have been reversed in mice. Whether this works in people or not is another story.

The researchers, based at MIT's Picower Institute for Learning and Memory, targeted an enzyme called PAK which affects the number, size and shape of connection between brain cells.

They found that inhibiting the enzyme stopped mice with Fragile X Syndrome behaving in erratic ways.

Prior to treatment they showed signs of hyperactivity, purposeless and repetitive movements.

Abnormalities corrected

Further analysis showed that not only were structural abnormalities in connections between brain cells righted, proper electrical communication was restored between the cells.

In the brain small protrusions called dendritic spines are responsible for communication between cells.

People with Fragile X Syndrome have more dendritic spines than usual, but each is longer and thinner, and transmits weaker electric signals.

Blocking PAK activity in the lab mice corrected these abnormalities.