In the Core Marvel Universe

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In the Core Marvel Universe, the most popular person is a 120 year-old Canadian berserker samurai who has who has been to the moon and was in love with a psychic who destroyed an alien planet and came back from the dead, married to both Japanese royalty and a green-haired terrorist, and had a child with a woman from a hidden region of Antarctica where dinosaurs and cavemen live. When he is not fighting his enemies -- most of whom are versions of himself, some of whom have claws made of lasers -- he reaffirms his status as as tough-as-nails loner as a member of at least three superhero teams.

And

In the Core Marvel Universe, the Punisher fought a giant bulletproof transvestite who survived being smothered by the fat of a morbidly obese man, decapitated, and thrown off the Empire State Building, in that order, before he was finally done in by a nuclear bomb.

This is considered one of the more serious Punisher storylines.